The g-factor of the charged leptons has always been considered by many physicists, both experimentaly as well as theoretically. In fact the electron and muon g-factor play the main role in testing the QED as well as the standard model. Meanwhile, there is a discrepancy between the standard model prediction of the muon anomalies magnetic moment and its experimental determination as large as (25.5±8.0) ×10-10.Therefore the g-factor can be used as the best place to study the new physics beyond the standard model. In this article, we consider the g-factor of the lepton in the noncommutative space time as a new physics model. In the ordinary theory, Schwinger evaluated the first correction to the g-factor of free electron, which arises from the electron interaction with photon at one loop level in the QED. In noncommutative space time, we show that at one loop, there is an NC-contribution to the g-factor of leptons which leads to a new bound on the noncommutative parameter (NC parameter). The obtained bounds are comparable with the current bounds on the NC-parameters of the order TeV.

Nowadays, the fundamental role of having a purpose for life in physical and mental health has been confirmed. According to victor frankl, presence of a purpose in life gives life a meaning and increases resilience against pains and traumas. The importance of the purpose in life construct reveals the need for a reliable and valid tool to measure it. Crumbaugh and Maholick's purpose in life questionnaire is the first and one of the most applied tools for the assessment of life's purposefulness. The aim of this research is to determine the factor structure of purpose in life questionnaire. The questionnaire was administered on 206 students who were selected through random stratified sampling at Ferdowsi University of Mashhad. Exploratory factor analysis showed that there are two factors "comprehension" and "purpose" and this finding were confirmed by confirmatory factor analysis. Altogether results of this research showed factor validity of the purpose in life questionnaire with a two factor pattern

Background and Objective: Extinction coefficient is the unique value to each protein and can evaluate the type and purity of recombinant protein produced in laboratories and factories producing recombinant proteins. In this study, a simple method for calculating the extinction coefficient of recombinant protein Granulocyte-Colony Stimulating Factor (G-CSF) is presented.Methods: G-CSF with concentration of 0.5 mg/ml was prepared from Arya Tina Gene. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) method was used to check the purity of the protein, then serial dilutions of 1.2 to 1.64 of the protein were prepared and using UV-VIS spectroscopy the optical density was measured.Results: Electrophoresis result as a single band of 18 kDa was observed. The results of UV-VIS spectroscopy of serial dilution were plotted as a distinct spectrograms and these were used to plot linear regression curve of the standard concentration of G-CSF.Conclusion: The results of this study shows the extinction coefficient equal to 0.81 M-1 cm-1 for recombinant G-CSF that was accordant with the number reports by international producers of G-CSF and suggests the correct method is used to calculate the physicochemical parameter.

Asthma is a chronic inflammatory and remodeling disorder of the airways, in which many cells, cellular elements, and cytokines play important roles. The role of tumor necrosis factor-a (TNF-a) in asthma is unclear in Pakistani population. The aim of this study was to assess the relationship between TNF-a -308 polymorphism and asthma.Polymorphism of TNF-a (G-308-A locus; rs 1800629) in 329 asthmatic patients and 151 healthy controls was evaluated. DNA was prepared from blood samples of cases and controls. Samples were genotyped for TNF-a 308 G/A polymorphism.There was no significant difference in the frequency of GG (OR 1.049 with 95% CI 0.68-1.63) and GA (OR 0.987 with 95% CI 0.64-1.53) genotypes of TNF-a-308. The AA genotype was absent in cases and only one AA genotype was observed in the controls.The genetic polymorphism of TNF-a does not seem to be associated with asthma in Pakistani population.

Introduction: IUI or injection of washed sperm into the uterine cavity is one of the assisted reproductive techniques that has been widely used in the treatment of infertility. This study was performed with aim to evaluate the effect of intrauterine injection of granulocyte stimulating factor (G-CSF) on the success rate of IUI in patients referred to the infertility center of Ardabil University of Medical Sciences. Methods: This clinical trial study was performed in 2019-2020 on 100 women with primary infertility referred to the Infertility Center of Ardabil University of Medical Sciences for IUI. The subjects were randomly divided into intervention and control groups each with 50 women. To stimulate ovulation for the women in two groups, clomiphene citrate was administered from the third to the fifth day of menstruation at a dose of 50-100 mg daily for five days and gonadotropin ampoules were administered with dose 150 mg at days 7 and 9 and after reaching to at least one follicle with 20 ml diameter, HCG was injected for the final maturation of the oocyte. In the intervention group, in addition to previous procedures on the day of HCG injection, 100 micrograms of G-CSF was injected intrauterine with IUI catheter, and then IUI was performed 36 hours later. Collected data were analyzed by SPSS (version 25). P<0. 05 was considered significant. Results: The success rate of IUI based on βHCG test was 20% in the case group and 4% in the control group, which showed a statistically significant difference in the success rate of pregnancy (p=0. 028). Conclusion: The results of the present study showed that G-CSF administration improves the chance of pregnancy compared to no treatment.